Enhancing recovery in coronary heart disease patients (ENRICHD): study design and methods. The ENRICHD investigators

Am Heart J. 2000 Jan;139(1 Pt 1):1-9. doi: 10.1016/s0002-8703(00)90301-6.


Psychosocial factors, particularly depression and lack of social support, are important predictors of morbidity and mortality in patients with coronary heart disease. This article describes the design and methods of the Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) study, a multicenter, randomized clinical trial involving 3000 patients enrolled after acute myocardial infarction. ENRICHD aims to investigate the effects of a psychosocial intervention that targets depression and/or low social support on survival and reinfarction among adult men and women who are at high risk for recurrent cardiac events because of psychosocial factors (depressive or social isolation). Design features include the use of an individually tailored yet standardized intervention, rigorous clinical trial methods, and enrollment of a large number of women and minorities.

Publication types

  • Clinical Trial
  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Antidepressive Agents / therapeutic use
  • Coronary Disease / mortality
  • Coronary Disease / psychology
  • Coronary Disease / rehabilitation*
  • Electrocardiography
  • Exercise Therapy / methods*
  • Female
  • Humans
  • Male
  • Patient Education as Topic
  • Prognosis
  • Psychology
  • Psychotherapy / methods*
  • Research Design*
  • Risk Factors
  • Secondary Prevention
  • Sertraline / therapeutic use
  • Surveys and Questionnaires
  • Survival Rate
  • United States / epidemiology


  • Antidepressive Agents
  • Sertraline