DNA chip technology ante portas

J Mol Med (Berl). 1999 Nov;77(11):761-8. doi: 10.1007/s001099900057.


The recent popularity of DNA chip technology has been fostered by the increasing demand for new diagnostic tools which allow the simultaneous analysis of large numbers of nucleic acid hybridization experiments in a timely fashion. The development of DNA chip-based assays has been strongly driven by modern approaches aiming at the comprehensive analysis of multiple gene mutations and expressed sequences. The broad range of current DNA chip applications include the detection of pathogens, the measurement of differences in the expression of genes between different cell populations, and the analysis of genomic alterations such as sequence and copy number alterations in disease-related genes and single nucleotide polymorphisms. We present an overview of the impact of DNA chip technology on the field of molecular medicine and discuss developments that can be expected in the near future.

Publication types

  • Review

MeSH terms

  • Animals
  • Communicable Diseases / diagnosis
  • Communicable Diseases / microbiology
  • Drug Therapy
  • Gene Expression Profiling*
  • Genetic Diseases, Inborn / diagnosis
  • Genetic Diseases, Inborn / genetics
  • Humans
  • Inflammation / therapy
  • Mutation
  • Nucleic Acid Hybridization
  • Oligonucleotide Array Sequence Analysis*
  • Polymorphism, Genetic
  • Vaccines / therapeutic use


  • Vaccines