The Effect of 5,8,11,14-eicosatetraynoic Acid on Lipid Metabolism

Lipids. 1979 Feb;14(2):181-93. doi: 10.1007/BF02533870.

Abstract

The purpose of this presentation is to review the current state of knowledge regarding 5,8,11,14-eicosatetraynoic acid (ETYA, Ro 3-1428) and its effects on lipid metabolism. Accordingly, the topics discussed include hypocholesterolemic and dermatological studies involving ETYA in both animals and man, as well as the effects of ETYA on desaturase enzymes. Metabolic studies involving ETYA are also noted. Primary interest is focused on the effects of ETYA on selected processes of arachidonate metabolism, and the effect of ETYA on inflammation, platelet aggregation and tumor growth are discussed, keeping in mind the relevance of arachidonate metabolism to these processes.

Publication types

  • Review

MeSH terms

  • 5,8,11,14-Eicosatetraynoic Acid / pharmacology*
  • 5,8,11,14-Eicosatetraynoic Acid / therapeutic use
  • Animals
  • Arachidonic Acids / metabolism
  • Cholesterol / metabolism
  • Dietary Fats / metabolism
  • Epoprostenol / biosynthesis
  • Fatty Acid Desaturases / metabolism
  • Fatty Acids, Unsaturated / pharmacology*
  • Humans
  • Indomethacin / pharmacology
  • Inflammation / drug therapy
  • Linoleic Acids / metabolism
  • Lipid Metabolism*
  • Lipoxygenase / metabolism
  • Liver / metabolism
  • Liver Neoplasms, Experimental / metabolism
  • Male
  • Papilloma / metabolism
  • Platelet Aggregation / drug effects
  • Prostaglandin-Endoperoxide Synthases / metabolism
  • Prostaglandins / biosynthesis
  • Sebaceous Glands / drug effects
  • Sebum / metabolism
  • Seminal Vesicles / metabolism
  • Thromboxane-A Synthase / metabolism

Substances

  • Arachidonic Acids
  • Dietary Fats
  • Fatty Acids, Unsaturated
  • Linoleic Acids
  • Prostaglandins
  • 5,8,11,14-Eicosatetraynoic Acid
  • Cholesterol
  • Epoprostenol
  • Lipoxygenase
  • Fatty Acid Desaturases
  • Prostaglandin-Endoperoxide Synthases
  • Thromboxane-A Synthase
  • Indomethacin