Screening for cervical neoplasia by self-assessment for human papillomavirus DNA

Lancet. 1999 Dec 4;354(9194):1970. doi: 10.1016/s0140-6736(99)04110-0.

Abstract

We evaluated self-collected vaginal human papillomavirus tests for cervical cancer screening and compared it with the specimens taken directly from the cervix in 247 patients at high-risk for cervical disease. The sample taken by the patient showed human papillomavirus DNA in a higher percentage than the sample taken by a doctor. Sensitivity of high-risk human papillomavirus types for high-grade cervical precursors (CIN 2/3) and invasive cervical cancers were 93% for both methods.

Publication types

  • Comparative Study
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biopsy
  • Cervical Intraepithelial Neoplasia / diagnosis
  • Colposcopy
  • Curettage
  • DNA, Viral / analysis*
  • Evaluation Studies as Topic
  • Female
  • Humans
  • Mass Screening / instrumentation
  • Mass Screening / methods*
  • Neoplasm Invasiveness
  • Papillomaviridae / genetics*
  • Papillomaviridae / isolation & purification
  • Precancerous Conditions / diagnosis
  • Prospective Studies
  • Self-Examination
  • Sensitivity and Specificity
  • Uterine Cervical Neoplasms / diagnosis*
  • Uterine Cervical Neoplasms / virology
  • Vaginal Smears / instrumentation
  • Vaginal Smears / methods*

Substances

  • DNA, Viral