Comparison of dopamine and noradrenaline release in mouse prefrontal cortex, striatum and hippocampus using microdialysis

Neurosci Lett. 1999 Dec 24;277(2):71-4. doi: 10.1016/s0304-3940(99)00840-x.


In vivo release of dopamine (DA) and noradrenaline (NA) in mouse medial prefrontal cortex, medial striatum and hippocampus was characterized using in vivo microdialysis. Basal release of NA was similar in these areas, but DA in striatum was 13-30 times higher than in other areas. Unconditioned stimuli (handling, novelty) induced strong increases, except for striatal DA. Striatal NA was more sensitive to handling than NA in other areas.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Corpus Striatum / metabolism*
  • Dopamine / metabolism*
  • Handling, Psychological*
  • Hippocampus / metabolism*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Microdialysis
  • Norepinephrine / metabolism*
  • Prefrontal Cortex / metabolism*


  • Dopamine
  • Norepinephrine