Abstract
Centaurea cyanus flower-heads are used in European phytotherapy for the treatment of minor ocular inflammations. Different pharmacological experiments (inhibition of carrageenan, zymosan and croton oil-induced oedemas, inhibition of plasma haemolytic activity, induction of anaphylatoxin activity) showed that polysaccharides extracted from C. cyanus flower-heads had anti-inflammatory properties and interfered with complement. Moreover, these polysaccharides were found to be mainly composed of galacturonic acid, arabinose, glucose, rhamnose and galactose.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anaphylatoxins / antagonists & inhibitors
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Animals
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Anti-Inflammatory Agents / therapeutic use*
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Asteraceae / chemistry*
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Carrageenan
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Complement Inactivator Proteins / pharmacology*
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Croton Oil
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Female
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Hemolysis / drug effects
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Inflammation / drug therapy
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Male
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Plant Extracts / therapeutic use*
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Polysaccharides / isolation & purification
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Polysaccharides / pharmacology*
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Rats
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Rats, Wistar
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Zymosan
Substances
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Anaphylatoxins
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Anti-Inflammatory Agents
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Complement Inactivator Proteins
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Plant Extracts
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Polysaccharides
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Croton Oil
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Carrageenan
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Zymosan