Giant cell angiofibroma of the buccal mucosa

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999 Dec;88(6):707-13. doi: 10.1016/s1079-2104(99)70014-4.


We report a case of a patient with a recently described entity (giant cell angiofibroma) occurring in the oral cavity. A submucosal solid tumor arising in the right buccal mucosa of a 46-year-old woman was histologically characterized by a patternless spindle-cell proliferation within a generally myxoid stroma containing areas of perivascular sclerosis. Numerous multinucleated giant cells of the floret type were present. Immunohistochemically, the tumor cells and multinucleated giant cells exhibited positivity for CD34. To the best of our knowledge, this is the first report of a giant cell angiofibroma arising in the oral cavity.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Angiofibroma / metabolism
  • Angiofibroma / pathology*
  • Biopsy
  • Cheek
  • Female
  • Humans
  • Immunohistochemistry
  • Middle Aged
  • Mouth Mucosa / metabolism
  • Mouth Mucosa / pathology
  • Mouth Neoplasms / metabolism
  • Mouth Neoplasms / pathology*
  • Sclerosis