Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions

Immunity. 1999 Dec;11(6):689-98. doi: 10.1016/s1074-7613(00)80143-0.

Abstract

The tumor necrosis factor family molecule Ox40-ligand (Ox40L) has been identified as a potential costimulatory molecule and also has been implicated in T cell homing and B cell activation. To ascertain the essential functions of Ox40L, we generated and characterized Ox40L-deficient mice. Mice lacking Ox40L exhibit an impaired contact hypersensitivity response, a dendritic cell-dependent T cell-mediated response, due to defects in T cell priming and cytokine production. In contrast, Ox40L-deficient mice do not have defects in T cell homing or humoral immune responses. In vitro, Ox40L-deficient dendritic cells are defective in costimulating T cell cytokine production. Thus, Ox40L has a critical costimulatory function in vitro and in vivo for dendritic cell:T cell interactions.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 3T3 Cells
  • Animals
  • Antigens, T-Independent / immunology
  • Dendritic Cells / immunology*
  • Dermatitis, Contact / immunology
  • Haptens / immunology
  • Hemocyanins / immunology
  • Hypersensitivity, Delayed / immunology
  • Membrane Glycoproteins*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Ovalbumin / immunology
  • Receptors, Tumor Necrosis Factor / genetics
  • Receptors, Tumor Necrosis Factor / immunology*
  • T-Lymphocytes / immunology*
  • Tumor Necrosis Factors

Substances

  • Antigens, T-Independent
  • Haptens
  • Membrane Glycoproteins
  • Receptors, Tumor Necrosis Factor
  • Tnfsf4 protein, mouse
  • Tumor Necrosis Factors
  • trinitrophenyl keyhole limpet hemocyanin
  • trinitrophenyl-ovalbumin
  • Ovalbumin
  • Hemocyanins