Sialochemistry in Sjögren's syndrome

Oral Surg Oral Med Oral Pathol. 1976 Feb;41(2):182-7. doi: 10.1016/0030-4220(76)90229-2.


The value of sialochemistry in the study of Sjögren's syndrome was explored by comparative examination of a spectrum of parotid components in twelve subjects with a positive diagnosis of the disease and twelve control subjects with normal gland function. The subjects with Sjögren's syndrome all exhibited a marked reduction in flow rate and phosphate concentration and a marked elevation in sodium and chloride concentration. The concentration of IgA was somewhat elevated (commensurate with reduced flow rate); the levels of IgG, IgM, and albumin were normal. The major functional abnormality in the parotid gland in Sjögren's syndrome appears to be luminal transport in the ductal region; leakage of serum components is minimal. Sialochemistry can be helpful in differentiating Sjögren's disease from other diseases of the salivary gland and in assessing degree of pathologic change.

MeSH terms

  • Adult
  • Aged
  • Chlorides / analysis
  • Female
  • Humans
  • Immunoglobulins / analysis
  • Middle Aged
  • Potassium / analysis
  • Saliva / analysis*
  • Sjogren's Syndrome / metabolism*
  • Sodium / analysis


  • Chlorides
  • Immunoglobulins
  • Sodium
  • Potassium