Novel intertypic recombinants of epstein-barr virus in the chinese population

R S Midgley; N W Blake; Q Y Yao; D Croom-Carter; S T Cheung; S F Leung; A T Chan; P J Johnson; D Huang; A B Rickinson; S P Lee

doi:10.1128/jvi.74.3.1544-1548.2000

Novel intertypic recombinants of epstein-barr virus in the chinese population

J Virol. 2000 Feb;74(3):1544-8. doi: 10.1128/jvi.74.3.1544-1548.2000.

Authors

R S Midgley¹, N W Blake, Q Y Yao, D Croom-Carter, S T Cheung, S F Leung, A T Chan, P J Johnson, D Huang, A B Rickinson, S P Lee

Affiliation

¹ CRC Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.

Abstract

Among 34 Epstein-Barr virus isolates from nonimmunocompromised Chinese donors, we identified three intertypic recombinants with type 1 sequences at the EBNA2 locus and type 2 sequences at some or all of the EBNA3A, -3B, and -3C loci. These appear to have arisen from independent, evolutionarily recent recombination events; such events may be commoner in nonimmunocompromised populations than hitherto imagined.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
Blood Donors
China
Epstein-Barr Virus Infections / virology*
Epstein-Barr Virus Nuclear Antigens / genetics*
Genotype
Herpesvirus 4, Human / classification*
Herpesvirus 4, Human / genetics*
Humans
Molecular Sequence Data
Polymerase Chain Reaction
Recombination, Genetic*
Sequence Analysis, DNA
Viral Matrix Proteins / genetics
Viral Proteins / genetics

Substances

EBNA-2 protein, Human herpesvirus 4
EBV-associated membrane antigen, Epstein-Barr virus
Epstein-Barr Virus Nuclear Antigens
Viral Matrix Proteins
Viral Proteins