Impaired recognition memory in monkeys after damage limited to the hippocampal region

J Neurosci. 2000 Jan 1;20(1):451-63. doi: 10.1523/JNEUROSCI.20-01-00451.2000.


Monkeys with lesions limited to the hippocampal region (the hippocampus proper, the dentate gyrus, and the subiculum) were impaired on two tasks of recognition memory: delayed nonmatching to sample and the visual paired-comparison task. Recognition memory was impaired in five different groups of monkeys, whether the lesions were made by an ischemic procedure, by radio frequency, or by ibotenic acid. The finding that the hippocampal region is essential for normal recognition memory performance is considered in the context of current ideas about the role of the hippocampus in declarative memory.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Behavior, Animal
  • Brain Ischemia / pathology
  • Brain Ischemia / physiopathology
  • Excitatory Amino Acid Agonists
  • Hippocampus / pathology*
  • Hippocampus / physiopathology*
  • Ibotenic Acid
  • Macaca fascicularis
  • Male
  • Nerve Degeneration / chemically induced
  • Pattern Recognition, Visual / physiology*
  • Photic Stimulation
  • Psychomotor Performance / physiology
  • Radio Waves


  • Excitatory Amino Acid Agonists
  • Ibotenic Acid