Simvastatin-induced lupus-like syndrome

Tenn Med. 2000 Jan;93(1):21-2.


The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors are widely used as cholesterol lowering agents that have an acceptable safety profile. As a group, this class of drugs has been associated with few immunologic reactions. Simvastatin (Zocor) has been linked to three cases of drug-induced lupus-like syndrome. We report the case of an additional patient who developed pleurisy and arthralgia after he started taking this low-density lipoprotein and cholesterol-lowering agent.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anticholesteremic Agents / adverse effects*
  • Arthralgia / chemically induced
  • Humans
  • Lupus Vulgaris / chemically induced*
  • Male
  • Pleurisy / chemically induced
  • Simvastatin / adverse effects*


  • Anticholesteremic Agents
  • Simvastatin