Abstract
Hydroxycinnamic acid esters of fukiic acid and piscidic acid were isolated from a 50% ethanolic extract obtained from the rhizomes of Cimicifuga racemosa (Ranunculaceae). Besides 2-E-caffeoylfukiic acid (fukinolic acid), 2-E-feruloylfukiic acid (cimicifugic acid A), 2-E-isoferuloylfukiic acid (cimicifugic acid B), 2-E-feruloylpiscidic acid (cimicifugic acid E) and 2-E-isoferuloylpiscidic acid (cimicifugic acid F), free caffeic, ferulic and isoferulic acids were isolated. The estrogenic activity of fukinolic acid was shown by increased proliferation (126% at 5 x 10(-8) M) of an estrogen dependent MCF-7 cell system with reference to estradiol (120% at 10(-10) M).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Esters
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Estrogens, Non-Steroidal / chemistry
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Estrogens, Non-Steroidal / isolation & purification
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Estrogens, Non-Steroidal / pharmacology*
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Humans
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Hydroxybenzoates / chemistry
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Hydroxybenzoates / isolation & purification
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Hydroxybenzoates / pharmacology*
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Phenylpropionates / chemistry
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Phenylpropionates / isolation & purification
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Phenylpropionates / pharmacology*
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Plants, Medicinal / chemistry*
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Succinates / chemistry
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Succinates / isolation & purification
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Succinates / pharmacology*
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Tumor Cells, Cultured
Substances
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Esters
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Estrogens, Non-Steroidal
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Hydroxybenzoates
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Phenylpropionates
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Succinates
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fukiic acid
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piscidic acid