Disproportional skeletal growth and markedly decreased bone mineral content in growth hormone receptor -/- mice

Biochem Biophys Res Commun. 2000 Jan 19;267(2):603-8. doi: 10.1006/bbrc.1999.1986.


Growth hormone (GH) is important for skeletal growth as well as for a normal bone metabolism in adults. The skeletal growth and adult bone metabolism was studied in mice with an inactivated growth hormone receptor (GHR) gene. The lengths of femur, tibia, and crown-rump were, as expected, decreased in GHR-/- mice. Unexpectedly, GHR-/- mice displayed disproportional skeletal growth reflected by decreased femur/crown-rump and femur/tibia ratios. GHR-/- mice demonstrated decreased width of the growth plates in the long bones and disturbed ossification of the proximal tibial epiphysis. Furthermore, the area bone mineral density (BMD) as well as the bone mineral content (BMC)/body weight were markedly decreased in GHR-/- mice. The decrease in BMC in GHR-/- mice was not due to decreased trabecular volumetric BMD but to a decreased cross-sectional cortical bone area In conclusion, GHR-/- mice demonstrate disproportional skeletal growth and markedly decreased bone mineral content.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Biomarkers / blood
  • Bone Density / genetics
  • Bone Density / physiology*
  • Bone Development / genetics
  • Bone Development / physiology*
  • DNA Primers / genetics
  • Femur / growth & development
  • Growth Hormone / physiology
  • Insulin-Like Growth Factor I / genetics
  • Insulin-Like Growth Factor I / metabolism
  • Male
  • Mice
  • Mice, Knockout
  • Organ Size
  • Organ Specificity
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Receptors, Somatotropin / deficiency*
  • Receptors, Somatotropin / genetics
  • Tibia / growth & development


  • Biomarkers
  • DNA Primers
  • RNA, Messenger
  • Receptors, Somatotropin
  • Insulin-Like Growth Factor I
  • Growth Hormone