Genetics of asthma and inflammation: the status

Curr Opin Immunol. 1999 Dec;11(6):606-9. doi: 10.1016/s0952-7915(99)00024-2.


Genome-wide screens are consistently finding linkage between asthma-associated traits and specific chromosomal loci. Several loci coincide with linkages to other inflammatory diseases, suggesting the presence of common pathways in their pathogenesis. Candidate-gene studies have found an association between a CD14 polymorphism and IgE levels, suggesting a mechanism for the increased prevalence of allergic disease. A polymorphism in Fc epsilon RI-beta shows parent-of-origin effects when associated with severe infantile eczema, further illustrating the complexity of gene-environment effects on the developing immune system.

Publication types

  • Review

MeSH terms

  • Asthma / genetics*
  • Forecasting
  • Humans
  • Inflammation / genetics*