The hereditary spastic paraplegias

J Neurol. 1999 Nov;246(11):995-1003. doi: 10.1007/s004150050503.


The hereditary spastic paraplegias are a complex group of neurodegenerative conditions which are characterised by slowly progressive lower limb spasticity. This article describes the main clinical features of pure and complicated hereditary spastic paraplegias and summarises recent advances in our understanding of the molecular genetics of these conditions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Diagnosis, Differential
  • Genes, Dominant
  • Genes, Recessive
  • Genetic Counseling
  • Genetic Linkage
  • Humans
  • Molecular Biology
  • Paraplegia / diagnosis
  • Paraplegia / genetics*
  • Paraplegia / physiopathology
  • Paraplegia / therapy
  • X Chromosome / genetics