Fc receptor signaling and trafficking: a connection for antigen processing

Immunol Rev. 1999 Dec;172:279-84. doi: 10.1111/j.1600-065x.1999.tb01372.x.


Most hematopoietic cells express a wide variety of receptors for the Fc portion of immunoglobulins (FcR) belonging to the immunoreceptor family. FcRs are multichain complexes composed of ligand-binding alpha chains, which determine Ig binding, and signal tranduction subunits, bearing a conserved immunoreceptor tyrosine-based activation motif (ITAM). Besides signaling, most Fc gamma Rs also efficiently internalize antigen-antibodies complexes and thus induce efficient processing of antigens into peptides presented by major histocompatibility complex (MHC) class II molecules. Importantly, ITAMs and cytosolic effectors of cell signaling also determine Fc gamma R's endocytic transport and antigen presentation capacities.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigen Presentation*
  • Biological Transport, Active
  • Dendritic Cells / immunology
  • Humans
  • Lysosomes / immunology
  • Lysosomes / metabolism
  • Receptors, Fc / chemistry
  • Receptors, Fc / metabolism*
  • Signal Transduction


  • Receptors, Fc