Treatment of conjunctival intraepithelial neoplasia with topical drops of mitomycin C

Cornea. 2000 Jan;19(1):1-6. doi: 10.1097/00003226-200001000-00001.


Purpose: To evaluate the efficacy and risks of complications of topical mitomycin C (MMC) for small-size conjunctival intraepithelial neoplasia (CIN).

Methods: Eight patients with clinically diagnosed CIN <8 mm were included in the study. Patients received topical drops of MMC, 0.02-0.04%, 4 times daily for 14 days. Retreatment was done when lesions were not eliminated or recurred after the first treatment.

Results: Three patients remained disease free after one course of MMC application. Retreatment was done in four patients because of lesions that decreased in size but were not eliminated, and for regrowth in one case. After retreatment, the lesions were eradicated in four patients, whereas in one patient, the treatment failed, and the lesion was surgically excised. The complications of MMC use included mild conjunctival hyperemia in two patients and mild allergy in one patient, which resolved after discontinuation of the treatment.

Conclusion: Application of topical MMC is an effective treatment for most but not all cases of small-size CIN.

Publication types

  • Case Reports
  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Antibiotics, Antineoplastic / administration & dosage
  • Antibiotics, Antineoplastic / therapeutic use*
  • Carcinoma in Situ / drug therapy*
  • Carcinoma in Situ / pathology
  • Conjunctival Neoplasms / drug therapy*
  • Conjunctival Neoplasms / pathology
  • Diagnosis, Differential
  • Female
  • Humans
  • Leukoplakia / drug therapy
  • Leukoplakia / pathology
  • Male
  • Middle Aged
  • Mitomycin / administration & dosage
  • Mitomycin / therapeutic use*
  • Ophthalmic Solutions / administration & dosage
  • Ophthalmic Solutions / therapeutic use


  • Antibiotics, Antineoplastic
  • Ophthalmic Solutions
  • Mitomycin