Clinical and magnetic resonance imaging findings in chronic sensory ganglionopathies

Ann Neurol. 2000 Jan;47(1):104-9.


Twenty-two of 29 patients with chronic sensory ataxic neuropathy showed T2-weighted magnetic resonance imaging high signal intensity in the posterior columns of the cervical spine. T2 changes reflected the degeneration of central sensory projections and localized the disease process to T-shaped dorsal root ganglion neurons. No similar abnormalities were found in sensory and sensorimotor length-dependent axonal neuropathy patients. Spinal cord magnetic resonance imaging is a useful tool to support the clinical diagnosis of primary ganglionopathy.

MeSH terms

  • Adolescent
  • Adult
  • Age of Onset
  • Aged
  • Ataxia / pathology*
  • Ataxia / physiopathology*
  • Child
  • Female
  • Hereditary Sensory and Autonomic Neuropathies / pathology*
  • Hereditary Sensory and Autonomic Neuropathies / physiopathology*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Spinal Cord / pathology