The effects of capsaicin on reflux, gastric emptying and dyspepsia

Aliment Pharmacol Ther. 2000 Jan;14(1):129-34. doi: 10.1046/j.1365-2036.2000.00682.x.


Aims: To evaluate capsaicin's effects on heartburn, dyspepsia, gastric acidity and emptying, and gastro-oesophageal reflux, and to test the hypothesis that capsaicin induces heartburn and exacerbates symptoms by sensitizing the oesophagus.

Methods: Eleven heartburn sufferers underwent two separate pH monitoring sessions and assessments of gastric emptying (13C-octanoic acid breath test), heartburn and dyspepsia (100 mm VAS) after a non-irritant meal. The meal consisted of a sausage biscuit with egg, cheese and 30 g raw onion, 8 oz chocolate milk and a peppermint patty. Thirty minutes prior to meal consumption, subjects were administered a placebo capsule. On visit 1, subjects consumed the meal containing 100 microl 13C-octanoic acid cooked in the egg, over 15 min. On visit 2, subjects consumed the meal plus 5 mg capsaicin in gelatin capsules.

Results: Oesophageal and gastric pH profiles and gastric emptying were not different between meals. Capsaicin did not alter mean heartburn and dyspepsia scores (P > 0.05), but significantly decreased time to peak heartburn (120 min vs. 247 min; P < 0.003). Time to peak dyspepsia was not altered by capsaicin (P > 0.05).

Conclusion: Capsaicin enhances noxious postprandial heartburn, presumably by direct effects on sensory neurons.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Capsaicin / adverse effects*
  • Dyspepsia / chemically induced*
  • Dyspepsia / physiopathology
  • Female
  • Gastric Emptying / drug effects*
  • Gastroesophageal Reflux / chemically induced*
  • Gastroesophageal Reflux / physiopathology
  • Heartburn / chemically induced
  • Humans
  • Hydrogen-Ion Concentration
  • Male
  • Manometry
  • Middle Aged


  • Capsaicin