Discovery of orally active nonpeptide vitronectin receptor antagonists based on a 2-benzazepine Gly-Asp mimetic

J Med Chem. 2000 Jan 13;43(1):22-6. doi: 10.1021/jm990446u.
No abstract available

MeSH terms

  • Animals
  • Benzazepines / chemical synthesis
  • Benzazepines / pharmacokinetics
  • Benzazepines / pharmacology*
  • Biological Availability
  • Bone Resorption / prevention & control
  • Cell Adhesion / drug effects
  • Cell Line
  • Half-Life
  • Humans
  • Molecular Mimicry
  • Osteoclasts / drug effects
  • Osteoclasts / metabolism
  • Pyridines / chemical synthesis
  • Pyridines / pharmacokinetics
  • Pyridines / pharmacology*
  • Rats
  • Receptors, Vitronectin / antagonists & inhibitors*
  • Stereoisomerism
  • Tissue Distribution

Substances

  • Benzazepines
  • Pyridines
  • Receptors, Vitronectin