Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 113 Pt 2, 193-205

Synthesis and Sorting of Proteoglycans

Affiliations
  • PMID: 10633071
Review

Synthesis and Sorting of Proteoglycans

K Prydz et al. J Cell Sci.

Abstract

Proteoglycans are widely expressed in animal cells. Interactions between negatively charged glycosaminoglycan chains and molecules such as growth factors are essential for differentiation of cells during development and maintenance of tissue organisation. We propose that glycosaminoglycan chains play a role in targeting of proteoglycans to their proper cellular or extracellular location. The variability seen in glycosaminoglycan chain structure from cell type to cell type, which is acquired by use of particular Ser-Gly sites in the protein core, might therefore be important for post-synthesis sorting. This links regulation of glycosaminoglycan synthesis to the post-Golgi fate of proteoglycans.

Similar articles

See all similar articles

Cited by 95 PubMed Central articles

See all "Cited by" articles

MeSH terms

LinkOut - more resources

Feedback