Co-infection of HHV-6 and HHV-8 Is Rare in Primary Effusion Lymphoma

Leuk Res. 2000 Jan;24(1):59-61. doi: 10.1016/s0145-2126(99)00144-7.

Abstract

The presence and distribution of Epstein-Barr virus (EBV), as well as human herpesvirus-6 and-8 (HHV-6 and HHV-8) was investigated by polymerase chain reaction in 191 samples from a variety of lymphoproliferative disorders. HHV-6 DNA was detected in 18% (30 of 169) of non-HHV-8 related lymphoproliferative disorders, with the highest frequency in AIDS-related lymphomas (8 of 25, 32%). In contrast, HHV-6 DNA was present in less than 5% (1 of 22) of HHV-8 related lymphoproliferative disorders [21 primary effusion lymphomas (PEL), and 1 cases of Castleman disease]. As compared to HHV-6, EBV DNA was frequently detected in PEL (11 of 19 samples, 58%). This study suggests that transformation to PEL is not enhanced by HHV-6, furthermore HHV-6 and -8 may interfere with each other.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Castleman Disease / epidemiology
  • Castleman Disease / virology
  • Cell Transformation, Neoplastic
  • Cell Transformation, Viral
  • Comorbidity
  • DNA, Viral / isolation & purification
  • Epstein-Barr Virus Infections / complications
  • Epstein-Barr Virus Infections / epidemiology
  • Herpesviridae Infections / complications
  • Herpesviridae Infections / epidemiology*
  • Herpesvirus 4, Human / isolation & purification
  • Herpesvirus 4, Human / pathogenicity
  • Herpesvirus 6, Human / isolation & purification*
  • Herpesvirus 6, Human / pathogenicity
  • Herpesvirus 8, Human / isolation & purification*
  • Herpesvirus 8, Human / pathogenicity
  • Humans
  • Japan / epidemiology
  • Lymphoma, AIDS-Related / epidemiology
  • Lymphoma, AIDS-Related / virology
  • Lymphoma, B-Cell / epidemiology
  • Lymphoma, B-Cell / virology*
  • Lymphoma, B-Cell, Marginal Zone / epidemiology
  • Lymphoma, B-Cell, Marginal Zone / virology
  • Lymphoma, Non-Hodgkin / epidemiology
  • Lymphoma, Non-Hodgkin / virology
  • Lymphoproliferative Disorders / epidemiology
  • Lymphoproliferative Disorders / virology
  • Polymerase Chain Reaction
  • Prevalence
  • Tumor Virus Infections / complications
  • Tumor Virus Infections / epidemiology*
  • Viral Interference

Substances

  • DNA, Viral