Memory--a century of consolidation

Science. 2000 Jan 14;287(5451):248-51. doi: 10.1126/science.287.5451.248.


The memory consolidation hypothesis proposed 100 years ago by Müller and Pilzecker continues to guide memory research. The hypothesis that new memories consolidate slowly over time has stimulated studies revealing the hormonal and neural influences regulating memory consolidation, as well as molecular and cellular mechanisms. This review examines the progress made over the century in understanding the time-dependent processes that create our lasting memories.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amnesia, Retrograde / physiopathology
  • Amygdala / physiology*
  • Animals
  • Brain / physiology*
  • Emotions
  • Hippocampus / physiology
  • Humans
  • Long-Term Potentiation
  • Memory / physiology*
  • Memory, Short-Term / physiology
  • Protein Kinases / metabolism
  • Receptors, Adrenergic, beta / physiology


  • Receptors, Adrenergic, beta
  • Protein Kinases