The association of resting heart rate with cardiovascular, cancer and all-cause mortality. Eight year follow-up of 3527 male Israeli employees (the CORDIS Study)

Eur Heart J. 2000 Jan;21(2):116-24. doi: 10.1053/euhj.1999.1741.


Background: Resting heart rate has frequently been shown to be a predictor of coronary heart disease mortality. Elevated heart rate could also be a marker for the presence of other risk factors, which have not been taken into consideration in previous studies.

Objective: To evaluate the effect of resting heart rate on the risk of all-cause cardiovascular and cancer mortality, taking into consideration haematological variables.

Method: The association between resting heart rate and mortality was assessed applying Cox's proportional hazard models to data obtained in an 8 year follow-up of 3527 Israeli male industrial employees. During this period 135 deaths were recorded, 57 from cardiovascular disease and 45 from cancer. Resting heart rate was assessed at entry; potential confounding demographic, anthropometric and socioeconomic variables, haematological data, serum lipid levels and health-related habits were accounted for.

Results: We found that the relative risk of all-cause mortality increased with increasing resting heart rate, workers with resting heart rate >90 beats. min(-1)had an adjusted relative risk of 2.23 (95% CI 1.4-3.6) compared with those with a heart rate <70 beats. min(-1). A similar result was achieved for cardiovascular disease mortality (adjusted relative risk 2.02, 95% CI 1.1-4.0). Cancer mortality was not associated with resting heart rate.

Conclusion: This study found that resting heart rate is associated with all-cause and cardiovascular disease mortality after controlling (in various statistical models) for platelet counts, haemoglobin concentration, white blood cell counts, total protein, and other recognized risk factors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Cardiovascular Diseases / diagnosis
  • Cardiovascular Diseases / mortality*
  • Cause of Death*
  • Coronary Disease / diagnosis
  • Coronary Disease / mortality
  • Follow-Up Studies
  • Heart Rate*
  • Humans
  • Israel / epidemiology
  • Male
  • Middle Aged
  • Neoplasms / diagnosis
  • Neoplasms / mortality*
  • Proportional Hazards Models
  • Survival Analysis