The effect of air pollution on exhaled nitric oxide of atopic and nonatopic subjects

Nitric Oxide. 1999 Dec;3(6):492-5. doi: 10.1006/niox.1999.0258.


Levels of exhaled nitric oxide (NO) were determined in well-characterized atopic and nonatopic subjects on 4 days with a different level of outdoor air pollution. The two groups matched well regarding spirometric values, i.e., no difference with regard to FEV(1), FVC, and peak flow. On the 4 test days asymptomatic atopic subjects exhaled 1.5- to 2.4-fold higher levels of NO compared with nonatopic subjects. In both groups the increase in exhaled NO in response to air pollution was similar (2.5 times maximal increase, P < 0.01). In conclusion, atopic subjects exhale higher levels of NO compared with nonatopic subjects, but respond to a similar degree to increased levels of air pollution.

MeSH terms

  • Adult
  • Air Pollution, Indoor*
  • Animals
  • Animals, Laboratory
  • Breath Tests
  • Female
  • Forced Expiratory Flow Rates
  • Forced Expiratory Volume
  • Humans
  • Hypersensitivity, Immediate / etiology
  • Hypersensitivity, Immediate / physiopathology*
  • Male
  • Medical Laboratory Personnel
  • Middle Aged
  • Nitric Oxide / metabolism*
  • Pulmonary Ventilation / physiology*
  • Reference Values
  • Skin Tests
  • Vital Capacity


  • Nitric Oxide