A compilation of cellular transcription factor interactions with the HIV-1 LTR promoter

Nucleic Acids Res. 2000 Feb 1;28(3):663-8. doi: 10.1093/nar/28.3.663.


The human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) represents a model promoter system and the identification and characterisation of cellular proteins that interact with this region has provided a basic understanding about both general eukaryotic and HIV-1 proviral transcriptional regulation. To date a large number of sequence-specific DNA-protein interactions have been described for the HIV-1 LTR. The aim of this report is to provide a comprehensive, updated listing of these HIV-1 LTR interactions. It is intended as a reference point to facilitate on-going studies characterising the identity of cellular proteins interacting with the HIV-1 LTR and the functional role(s) of specific regions of the LTR for HIV-1 replication.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • DNA-Binding Proteins / metabolism*
  • Enhancer Elements, Genetic / genetics
  • Gene Expression Regulation, Viral / genetics
  • HIV Long Terminal Repeat / genetics*
  • HIV-1 / genetics*
  • Humans
  • Promoter Regions, Genetic / genetics*
  • Response Elements / genetics
  • Transcription Factors / metabolism*


  • DNA-Binding Proteins
  • Transcription Factors