Causes and Consequences of Tumour Acidity and Implications for Treatment

Mol Med Today. 2000 Jan;6(1):15-9. doi: 10.1016/s1357-4310(99)01615-9.

Abstract

Tumour cells have a lower extracellular pH (pHe) than normal cells; this is an intrinsic feature of the tumour phenotype, caused by alterations either in acid export from the tumour cells or in clearance of extracellular acid. Low pHe benefits tumour cells because it promotes invasiveness, whereas a high intracellular pH (pHi) gives them a competitive advantage over normal cells for growth. Molecular genetic approaches have revealed hypoxia-induced coordinated upregulation of glycolysis, a potentially important mechanism for establishing the metabolic phenotype of tumours. Understanding tumour acidity opens up new opportunities for therapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / metabolism
  • Extracellular Space / chemistry
  • Extracellular Space / metabolism
  • Glycolysis
  • Humans
  • Hydrogen-Ion Concentration
  • Lactic Acid / metabolism
  • Neoplasms / chemistry
  • Neoplasms / drug therapy
  • Neoplasms / metabolism*
  • Neoplasms / pathology

Substances

  • Antineoplastic Agents
  • Lactic Acid