Multiple physiological functions for multidrug transporter P-glycoprotein?

Trends Biochem Sci. 2000 Jan;25(1):1-6. doi: 10.1016/s0968-0004(99)01493-0.


Multidrug resistance mediated by the drug-efflux protein P-glycoprotein (P-gp) is one mechanism that tumor cells use to escape death induced by chemotherapeutic drugs. Although it is irrefutable that P-gp can efflux xenobiotics out of cells, biological regulatory functions for P-gp in multicellular organisms have yet to be established firmly. Recent observations have challenged the notion that P-gp has evolved merely to efflux xenotoxins out of healthy cells and raised the possibility that P-gp and related transporter molecules might play a fundamental role in regulating cell differentiation, proliferation and survival.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / physiology*
  • Animals
  • Biological Transport
  • Cell Death / physiology*
  • Cell Differentiation / physiology*
  • Cholesterol / metabolism
  • Drug Resistance, Multiple / physiology
  • Humans
  • Lipid Metabolism


  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Cholesterol