Abstract
The assembly and disassembly (i.e. turnover) of actin filaments in response to extracellular signals underlie a wide variety of basic cellular processes such as cell division, endocytosis and motility. The bulk turnover of subunits is 100-200 times faster in cells than with pure actin, suggesting a complex regulation in vivo. Significant progress has been made recently in identifying and clarifying the roles of several cellular proteins that coordinately regulate actin-filament turnover.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Actin Cytoskeleton / metabolism*
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Actin Cytoskeleton / ultrastructure
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Actin Depolymerizing Factors
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Actins / metabolism*
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Adenosine Diphosphate / metabolism
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Adenosine Triphosphate / metabolism
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Animals
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Humans
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Microfilament Proteins / genetics
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Microfilament Proteins / metabolism*
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Thymosin / metabolism
Substances
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Actin Depolymerizing Factors
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Actins
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Microfilament Proteins
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Thymosin
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Adenosine Diphosphate
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Adenosine Triphosphate