Regulating actin-filament dynamics in vivo

Trends Biochem Sci. 2000 Jan;25(1):19-23. doi: 10.1016/s0968-0004(99)01511-x.


The assembly and disassembly (i.e. turnover) of actin filaments in response to extracellular signals underlie a wide variety of basic cellular processes such as cell division, endocytosis and motility. The bulk turnover of subunits is 100-200 times faster in cells than with pure actin, suggesting a complex regulation in vivo. Significant progress has been made recently in identifying and clarifying the roles of several cellular proteins that coordinately regulate actin-filament turnover.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Actin Cytoskeleton / metabolism*
  • Actin Cytoskeleton / ultrastructure
  • Actin Depolymerizing Factors
  • Actins / metabolism*
  • Adenosine Diphosphate / metabolism
  • Adenosine Triphosphate / metabolism
  • Animals
  • Humans
  • Microfilament Proteins / genetics
  • Microfilament Proteins / metabolism*
  • Thymosin / metabolism


  • Actin Depolymerizing Factors
  • Actins
  • Microfilament Proteins
  • Thymosin
  • Adenosine Diphosphate
  • Adenosine Triphosphate