Mass spectrometry. From genomics to proteomics

Trends Genet. 2000 Jan;16(1):5-8. doi: 10.1016/s0168-9525(99)01879-x.


Large-scale DNA sequencing has stimulated the development of proteomics by providing a sequence infrastructure for protein analysis. Rapid and automated protein identification can be achieved by searching protein and nucleotide sequence databases directly with data generated by mass spectrometry. A high-throughput and large-scale approach to identifying proteins has been the result. These technological changes have advanced protein expression studies and the identification of proteins in complexes, two types of studies that are essential in deciphering the networks of proteins that are involved in biological processes.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Databases, Factual
  • Genome*
  • Mass Spectrometry / methods*
  • Proteins / chemistry
  • Proteome*


  • Proteins
  • Proteome