TGF beta-related pathways. Roles in Caenorhabditis elegans development

Trends Genet. 2000 Jan;16(1):27-33. doi: 10.1016/s0168-9525(99)01916-2.


Genetic and molecular analysis in Caenorhabditis elegans has produced new insights into how TGF beta-related pathways transduce signals and the developmental processes in which they function. These pathways are essential regulators of dauer formation, body-size determination, male copulatory structures and axonal guidance. Here, we review the insights that have come from standard molecular genetic experiments and discuss how the recently completed genome sequence has contributed to our understanding of these pathways.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Bone Morphogenetic Proteins / genetics
  • Bone Morphogenetic Proteins / metabolism
  • Bone Morphogenetic Proteins / physiology
  • Caenorhabditis elegans / genetics*
  • Caenorhabditis elegans / growth & development
  • Caenorhabditis elegans / metabolism
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism
  • Carrier Proteins / physiology
  • Helminth Proteins / genetics
  • Helminth Proteins / metabolism
  • Helminth Proteins / physiology*
  • Male
  • Signal Transduction / genetics*
  • Transforming Growth Factor beta / genetics*
  • Transforming Growth Factor beta / metabolism


  • Bone Morphogenetic Proteins
  • Carrier Proteins
  • Helminth Proteins
  • Transforming Growth Factor beta