The spe-10 mutant has longer life and increased stress resistance

Neurobiol Aging. Sep-Oct 1999;20(5):503-12. doi: 10.1016/s0197-4580(99)00085-8.


We investigated the life span of spe-10 mutant nematodes. We also tested resistance of spe-10 mutants to ultraviolet (UV) light, heat, and paraquat and examined the relationship between resistance to UV light and the fertility defect of these animals. The spe-10 mutation significantly increased mean life span. Additionally, the mutation significantly increased resistance to both UV light and to heat. Resistance to paraquat was not significantly different from that of wild-type, nor were any dauers formed at 27 degrees C. No significant correlation was found between the UV resistance and the fertility defect, nor was the UV resistance attributable to a hormetic effect. These results reinforce the importance of stress resistance in specifying increased life span and indirectly suggest that this fertility defect is not a direct cause of life span extension.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Caenorhabditis elegans / genetics*
  • Caenorhabditis elegans / growth & development
  • Caenorhabditis elegans / metabolism*
  • Drug Resistance
  • Fertility
  • Genes, Helminth / genetics
  • Genes, Helminth / physiology*
  • Helminth Proteins / genetics
  • Helminth Proteins / physiology
  • Herbicides / pharmacology
  • Hot Temperature
  • Longevity / drug effects
  • Longevity / genetics*
  • Longevity / radiation effects
  • Mutation / physiology
  • Oxidative Stress / genetics
  • Paraquat / pharmacology
  • Temperature
  • Ultraviolet Rays


  • Helminth Proteins
  • Herbicides
  • Paraquat