Vertebral and rib sarcoidosis: long-term clinical remission with methotrexate

Clin Rheumatol. 1999;18(6):492-4. doi: 10.1007/s100670050145.


We describe a patient with bilateral hilar lymphadenopathy shown on a chest radiograph and supraclavicular lymphadenopathy. Biopsy of a supraclavicular lymph node showed non-caseating granulomas. A diagnosis of sarcoidosis was made and no treatment was given. One year later she complained of cervical and lumbar pain and decreasing strength of the right hand. Magnetic resonance imaging of the spine showed multiple lesions within the vertebral bodies of six vertebrae, and thoracic computed tomography showed partial destruction of the first right rib. A biopsy of the second lumbar vertebra demonstrated non-caseating granulomas. Corticosteroid treatment was unsuccessful and long-term remission of the symptoms was achieved with a weekly low dose of methotrexate.

Publication types

  • Case Reports

MeSH terms

  • Bone Diseases / diagnostic imaging
  • Bone Diseases / drug therapy*
  • Female
  • Humans
  • Immunosuppressive Agents / therapeutic use*
  • Lumbar Vertebrae / diagnostic imaging
  • Lumbar Vertebrae / drug effects*
  • Methotrexate / therapeutic use*
  • Middle Aged
  • Remission Induction
  • Ribs / diagnostic imaging
  • Ribs / drug effects*
  • Sarcoidosis / diagnostic imaging
  • Sarcoidosis / drug therapy*
  • Tomography, X-Ray Computed
  • Treatment Outcome


  • Immunosuppressive Agents
  • Methotrexate