Pharmacokinetics of 1M gadobutrol in patients with chronic renal failure

Invest Radiol. 2000 Jan;35(1):35-40. doi: 10.1097/00004424-200001000-00004.


Rationale and objectives: To investigate the pharmacokinetics of 1M gadobutrol as a new neutral MR contrast agent in patients with impaired renal function.

Methods: Twenty-one patients with impaired renal function and any indication for a contrast-enhanced MRI were enrolled into this prospective study and classified in two subgroups according to their creatinine clearance (group 1, 30-80 mL/ min; group 2, 30 mL/min or less, not requiring dialysis). Eleven patients were assigned to the lower dose of 0.1 mmol Gd/kg and 10 patients to the higher dose of 0.3 mmol Gd/kg. To calculate pharmacokinetic parameters, urine and venous blood samples were drawn at baseline and up to 72 hours for group 1 and 120 hours for group 2 after administration of gadobutrol.

Results: The predominant extracellular distribution of gadobutrol at steady state did not change according to the degree of renal impairment. The mean elimination half-life of gadobutrol increased to 7.4 +/- 2.6 hours (0.1 mmol/kg) and 5.4 +/- 1.5 hour (0.3 mmol/kg) in group 1 and to 17.9 +/- 6.2 hours (0.1 mmol/kg) and 20.4 +/- 16.9 hours (0.3 mmol/kg) in group 2, compared with 1.5 hours in healthy volunteers. The relation between serum (tbeta) and urine (t(elim)) elimination half-lives, as well as total serum and renal clearance, indicated renal elimination as the main pathway of elimination. The recovery of gadobutrol in the urine of group 1 was complete within 72 hours for both dosage levels. Patients with severe renal impairment showed a mean recovery of 80.1% (0.1 mmol/kg) and 85.3% (0.3 mmol/kg) within the observation period of 120 hours.

Conclusions: The half-life of gadobutrol is prolonged in patients with impaired renal function, but elimination by means of the kidneys is the predominant route.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Case-Control Studies
  • Contrast Media / pharmacokinetics*
  • Female
  • Gadolinium
  • Half-Life
  • Humans
  • Kidney / metabolism
  • Kidney Failure, Chronic / metabolism*
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Organometallic Compounds / pharmacokinetics*
  • Prospective Studies
  • Tissue Distribution


  • Contrast Media
  • Organometallic Compounds
  • gadobutrol
  • Gadolinium