In vitro activities of ketoconazole, econazole, miconazole, and Melaleuca alternifolia (tea tree) oil against Malassezia species

Antimicrob Agents Chemother. 2000 Feb;44(2):467-9. doi: 10.1128/AAC.44.2.467-469.2000.


The in vitro activities of ketoconazole, econazole, miconazole, and tea tree oil against 54 Malassezia isolates were determined by agar and broth dilution methods. Ketoconazole was more active than both econazole and miconazole, which showed very similar activities. M. furfur was the least susceptible species. M. sympodialis, M. slooffiae, M. globosa, and M. obtusa showed similar susceptibilities to the four agents.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / pharmacology*
  • Econazole / pharmacology
  • Humans
  • Ketoconazole / pharmacology
  • Malassezia / drug effects*
  • Miconazole / pharmacology
  • Microbial Sensitivity Tests
  • Rosales / chemistry
  • Tea Tree Oil / chemistry
  • Tea Tree Oil / pharmacology*


  • Antifungal Agents
  • Tea Tree Oil
  • Econazole
  • Miconazole
  • Ketoconazole