Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformans

Infect Immun. 2000 Feb;68(2):982-5. doi: 10.1128/IAI.68.2.982-985.2000.

Abstract

The calcineurin gene was cloned and disrupted in serotype D strains of Cryptococcus neoformans. Serotype A and serotype D calcineurin mutants were inviable at 37 degrees C and avirulent in mice, whereas only serotype A mutants were cation stress sensitive. Thus, calcineurin plays conserved and divergent roles in serotype A and serotype D strains.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • Calcineurin / genetics
  • Calcineurin / physiology*
  • Cryptococcus neoformans / classification
  • Cryptococcus neoformans / growth & development
  • Cryptococcus neoformans / pathogenicity*
  • Mice
  • Mice, Inbred BALB C
  • Molecular Sequence Data
  • Mutation
  • Serotyping
  • Virulence

Substances

  • Calcineurin