Vascularization is decreased in pulmonary adenocarcinoma expressing brain-specific angiogenesis inhibitor 1 (BAI1)

Int J Mol Med. 2000 Feb;5(2):181-3. doi: 10.3892/ijmm.5.2.181.


Brain-specific angiogenesis inhibitor 1 (BAI1) is a novel angioinhibitory factor. We examined BAI1 gene expression in 48 pulmonary adenocarcinoma specimens by RT-PCR. Vascular density (number and measurement area) was immunohistochemically evaluated in tumor specimens using anti-CD34 monoclonal antibody. BAI1 gene expression was detected in 38 of 48 pulmonary adenocarcinomas (79. 2%). Vascular number and measurement area were significantly decreased in the BAI1-positive pulmonary adenocarcinomas (19.3+/-4. 4/microm2 and 1.7+/-0.6%) as compared with those in the BAI1-negative carcinomas (75.5+/-42.7/microm2 and 5.5+/-1.5%) (Mann-Whitney U-test, p=0.0017). These results suggest that BAI1 expression may inhibit stromal vascularization in pulmonary adenocarcinoma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Adenocarcinoma / blood supply*
  • Adenocarcinoma / pathology
  • Cell Adhesion Molecules
  • Cell Adhesion Molecules, Neuronal / metabolism*
  • Guanylate Kinases
  • Humans
  • Immunohistochemistry
  • Lung Neoplasms / blood supply*
  • Lung Neoplasms / pathology
  • Neovascularization, Pathologic / metabolism*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Statistics, Nonparametric


  • Adaptor Proteins, Signal Transducing
  • Cell Adhesion Molecules
  • Cell Adhesion Molecules, Neuronal
  • Guanylate Kinases
  • MAGI1 protein, human