Abstract
We report the sequence, tissue distribution, and chromosome location of a novel gene, PDCD9 (programmed cell death 9). PDCD9 is the mammalian counterpart of the Gallus gallus pro-apoptotic protein p52. The human cDNA has an open reading frame of 1,314 nucleotides and was predicted to encode a protein of 438 amino acids with a calculated mass of 50 kDa. The protein sequences of chicken, mouse, and human PDCD9 are remarkably conserved. PDCD9 mRNA is expressed ubiquitously in adult tissues, displaying a stronger signal in heart, skeletal muscle, kidney, and liver. PDCD9 was mapped to chromosome 5q11.
Copyright 1999 S. Karger AG, Basel
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Apoptosis / genetics
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Cell Cycle Proteins / chemistry*
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Cell Cycle Proteins / genetics*
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Cell Cycle Proteins / metabolism
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Chickens / genetics*
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Chromosomes, Human, Pair 5 / genetics
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Cloning, Molecular
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Conserved Sequence / genetics
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Expressed Sequence Tags
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Humans
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In Situ Hybridization, Fluorescence
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Mice
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Molecular Sequence Data
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Physical Chromosome Mapping*
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RNA, Messenger / analysis
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RNA, Messenger / genetics
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Sequence Alignment
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Sequence Homology, Amino Acid
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Viral Proteins / chemistry*
Substances
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Cell Cycle Proteins
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RNA, Messenger
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Viral Proteins
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protein p52, mammalian