Study of erythrocyte sedimentation behavior by piezoelectric crystal impedance sensor

Biosens Bioelectron. 1999 Dec;14(8-9):689-94. doi: 10.1016/s0956-5663(99)00047-0.


Based on the impedance characteristic of erythrocytes at high frequency, the response of piezoelectric crystal impedance (PCI) sensor in the erythrocyte suspension was derived and verified experimentally. A method of using PCI sensor to investigate erythrocyte aggregation-sedimentation phenomenon was proposed. From the frequency response of the PCI sensor, the erythrocyte aggregation time and sedimentation rate could be obtained during erythrocyte aggregation and sedimentation. With the present method, the effects of the erythrocyte deformability, the osmotic pressure and the coexisting macromolecules on the erythrocyte sedimentation rate were studied. The results show that the PCI sensor possesses some advantages, such as good sensitivity, simplicity of use and no thermal effect for the impedance study of erythrocyte aggregation and sedimentation.

MeSH terms

  • Blood Sedimentation*
  • Electronics, Medical / instrumentation*
  • Electronics, Medical / methods
  • Electronics, Medical / statistics & numerical data
  • Erythrocyte Aggregation
  • Erythrocyte Deformability
  • Evaluation Studies as Topic
  • Hemorheology / instrumentation*
  • Hemorheology / methods
  • Hemorheology / statistics & numerical data
  • Humans
  • In Vitro Techniques
  • Macromolecular Substances
  • Male
  • Osmotic Pressure
  • Sensitivity and Specificity


  • Macromolecular Substances