CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis

Mech Dev. 2000 Feb;90(2):181-93. doi: 10.1016/s0925-4773(99)00248-8.


Development of the vertebrate central nervous system is thought to be controlled by intricate cell-cell interactions and spatio-temporally regulated gene expressions. The details of these processes are still not fully understood. We have isolated a novel vertebrate gene, CRIM1/Crim1, in human and mouse. Human CRIM1 maps to chromosome 2p21 close to the Spastic Paraplegia 4 locus. Crim1 is expressed in the notochord, somites, floor plate, early motor neurons and interneuron subpopulations within the developing spinal cord. CRIM1 appears to be evolutionarily conserved and encodes a putative transmembrane protein containing an IGF-binding protein motif and multiple cysteine-rich repeats similar to those in the BMP-associating chordin and sog proteins. Our results suggest a role for CRIM1/Crim1 in CNS development possibly via growth factor binding.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amino Acid Sequence
  • Animals
  • Blotting, Northern
  • Brain / embryology
  • Chromosomes, Human, Pair 2
  • Conserved Sequence
  • Evolution, Molecular
  • Female
  • Gene Expression Regulation, Developmental*
  • Humans
  • In Situ Hybridization / methods
  • Invertebrates
  • Membrane Proteins / genetics*
  • Mice
  • Molecular Sequence Data
  • Nuclear Proteins*
  • Proteins*
  • Proto-Oncogene Proteins c-myc / genetics
  • RNA, Messenger
  • Restriction Mapping
  • Sequence Homology, Amino Acid
  • Spinal Cord / embryology
  • Tissue Distribution
  • Vertebrates


  • CRIM1 protein, human
  • Membrane Proteins
  • Nuclear Proteins
  • Proteins
  • Proto-Oncogene Proteins c-myc
  • RNA, Messenger
  • cysteine-rich protein, mammalian