Mouse BTEB3, a new member of the basic transcription element binding protein (BTEB) family, activates expression from GC-rich minimal promoter regions

Biochem J. 2000 Feb 1;345 Pt 3(Pt 3):529-33.

Abstract

Members of the three-zinc-finger family of transcription factors play an important role in determining basal transcription. We have cloned mouse BTEB3 (mBTEB3), a new member of the basic transcription element binding protein (BTEB) family, which is expressed in a wide variety of tissues. mBTEB3 activates transcription of the simian virus 40 early promoter (4-fold) and of the tissue-specific SM22alpha promoter (100-fold), suggesting that, like BTEB1 and Sp1, mBTEB3 is a basal transcription factor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cell Cycle Proteins*
  • Cloning, Molecular
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • GC Rich Sequence
  • Gene Expression Regulation, Developmental
  • Kruppel-Like Transcription Factors
  • Mice
  • Microfilament Proteins / genetics
  • Molecular Sequence Data
  • Muscle Proteins / genetics
  • Promoter Regions, Genetic
  • Repressor Proteins*
  • Sequence Homology, Amino Acid
  • Trans-Activators / genetics*
  • Trans-Activators / metabolism*
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*

Substances

  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • KLF9 protein, human
  • Klf13 protein, mouse
  • Klf9 protein, mouse
  • Kruppel-Like Transcription Factors
  • Microfilament Proteins
  • Muscle Proteins
  • Repressor Proteins
  • Tagln protein, mouse
  • Trans-Activators
  • Transcription Factors
  • transgelin

Associated data

  • GENBANK/AJ245644