Acute Hepatitis B After Autologous Stem Cell Transplantation in a Man Previously Infected by Hepatitis B Virus

Bone Marrow Transplant. 1999 Dec;24(11):1243-4. doi: 10.1038/sj.bmt.1702039.


We report a case of acute hepatitis B after autologous stem cell transplantation (ASCT) in a patient with low-grade non-Hodgkin's lymphoma. At diagnosis of the hematological disease, the patient had the characteristic serology of a previous hepatitis B infection, being Ag HBs negative, hepatitis B virus core antibody positive (anti-HBC) and hepatitis B virus surface antibody weakly positive. He developed fatal hepatitis B after autologous stem cell transplantation, suggesting reactivation consequent to immunosuppression.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Hepatitis B / etiology*
  • Hepatitis B / transmission
  • Hepatitis B Antibodies / blood
  • Hepatitis B Antigens / blood
  • Hepatitis B virus / isolation & purification
  • Humans
  • Immunosuppression / adverse effects
  • Lymphoma, Non-Hodgkin / therapy
  • Lymphoma, Non-Hodgkin / virology
  • Male
  • Middle Aged
  • Transplantation, Autologous / adverse effects


  • Hepatitis B Antibodies
  • Hepatitis B Antigens