Nitric oxide and portal hypertension: its role in the regulation of intrahepatic and splanchnic vascular resistance

Semin Liver Dis. 1999;19(4):411-26. doi: 10.1055/s-2007-1007129.


In recent years it has become well established that nitric oxide (NO) plays a crucial role in the hemodynamic abnormalities that develop in chronic portal hypertension. The purpose of this review is to summarize the available data and current concepts regarding the involvement of NO in the pathophysiologic changes in the micro-circulation of the liver and the splanchnic and systemic circulation that associate portal hypertension.

Publication types

  • Review

MeSH terms

  • Animals
  • Collateral Circulation / physiology
  • Endothelins / physiology
  • Hemodynamics
  • Humans
  • Hypertension, Portal / physiopathology*
  • Liver Circulation / physiology*
  • Liver Cirrhosis / physiopathology
  • Nitric Oxide / physiology*
  • Splanchnic Circulation / physiology*
  • Vascular Resistance / physiology*


  • Endothelins
  • Nitric Oxide