Anti-plasmodial sesquiterpenoids from the African Reneilmia cincinnata

M H Tchuendem; J A Mbah; A Tsopmo; J F Ayafor; O Sterner; C C Okunjic; M M Iwu; B M Schuster

doi:10.1016/s0031-9422(99)00344-1

Anti-plasmodial sesquiterpenoids from the African Reneilmia cincinnata

Phytochemistry. 1999 Nov;52(6):1095-9. doi: 10.1016/s0031-9422(99)00344-1.

Authors

M H Tchuendem¹, J A Mbah, A Tsopmo, J F Ayafor, O Sterner, C C Okunjic, M M Iwu, B M Schuster

Affiliation

¹ Chemistry Department, Faculty of Science, University of Dschang, Cameroon.

PMID: 10643672
DOI: 10.1016/s0031-9422(99)00344-1

Abstract

A new isodaucane sesquiterpenoid, 6,7,10-trihydoxyisodaucane, was isolated from the fruits of Reneilmia cincinnata, together with the known sesquiterpenoids oplodiol, oplopanone, 5E,10(14)-germacradien-1 beta, 4 beta-diol, 1(10)E,5E-germacradien-4 alpha-ol and eudesman-1,4,7-triol. A large amount of 5-hydroxy-3,7,4'-trimethoxyflavone was also isolated. Their structures were established by NMR techniques using 1D and 2D experiments. Three of the known sesquirernenoids exhibited noteworthy anti-plasmodial activity against Plasmodium falciparum strains.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Animals
Antimalarials / chemistry
Antimalarials / isolation & purification*
Antimalarials / pharmacology*
Fruit / chemistry
Nuclear Magnetic Resonance, Biomolecular
Plant Extracts / chemistry
Plant Extracts / isolation & purification
Plant Extracts / pharmacology
Plasmodium falciparum / drug effects
Plasmodium falciparum / growth & development
Sesquiterpenes / chemistry
Sesquiterpenes / isolation & purification*
Sesquiterpenes / pharmacology*
Zingiberales / chemistry*

Substances

Antimalarials
Plant Extracts
Sesquiterpenes