Angiotensin-converting enzyme genotype is associated with Alzheimer disease in the Japanese population

Neurosci Lett. 1999 Dec 17;277(1):65-7. doi: 10.1016/s0304-3940(99)00827-7.


We compared the distribution of an insertion (I)/deletion (D) polymorphism of the gene coding for the angiotensin-converting enzyme (ACE) in 133 Japanese sporadic Alzheimer disease (AD) patients with 257 controls. The association between AD and ACE genotypes or alleles was found to be significant. The frequency of II genotypes was 1.4 times higher in AD than controls, while that of DD genotypes was only 0.4 times as high. The altered distribution of ACE alleles in patients with AD appeared to be independent of apolipoprotein E.

MeSH terms

  • Aged
  • Alzheimer Disease / enzymology*
  • Alzheimer Disease / genetics*
  • Brain Chemistry / genetics
  • Gene Frequency / genetics
  • Genotype
  • Humans
  • Japan
  • Peptidyl-Dipeptidase A / genetics*
  • Polymorphism, Genetic / genetics
  • Risk Factors


  • Peptidyl-Dipeptidase A