Pleural mesothelioma and membranous nephropathy

Nephron. 2000 Jan;84(1):71-4. doi: 10.1159/000045541.


Underlying malignancy has been thought to be responsible for 5-10% of the cases of membranous nephropathy in adults, with the risk being highest in patients over the age of 60 years. Solid tumors such as carcinomas of lung or colon, are most often involved. It is presumed that tumor antigens are deposited in the glomeruli; this is followed by antibody deposition and complement activation, leading to epithelial cell and basement membrane injury and proteinuria due to the associated increase in glomerular permeability. We describe a patient with a resistant nephrotic syndrome and massive proteinuria due to membranous nephropathy associated with pleural mesothelioma.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Antigen-Antibody Complex / metabolism
  • Glomerulonephritis, Membranous / etiology*
  • Glomerulonephritis, Membranous / immunology
  • Glomerulonephritis, Membranous / pathology
  • Humans
  • Male
  • Mesothelioma / complications*
  • Mesothelioma / immunology
  • Middle Aged
  • Nephrotic Syndrome / etiology
  • Pleural Neoplasms / complications*
  • Pleural Neoplasms / immunology
  • Prognosis
  • Proteinuria / etiology


  • Antigen-Antibody Complex