Tamm-Horsfall protein (THP), the most abundant glycoprotein in normal human urine, is produced by kidney. THP is heavily glycosylated by N-linked glycans, which are responsible for most of its properties. The sugar moiety is also modified in some diseases. THP plays an important role in ion transport and in maintaining water impermeability of the TALH and also protects the urinary system from uropathogens. It is also involved in immunoregulatory processes. THP was reported to influence many pathological conditions, such as formation of kidney stones, development of interstitial nephritis and tubular blockade.