Investigation of the modern major crime scene is no longer an isolated endeavor confined to law enforcement. Recent advances in forensic science, especially forensic nursing, and the recognized need to include a broad range of professionals in the quest for justice and the quality of community life has demanded that the examination of major crimes requires a multidisciplinary team approach. This article documents the necessity for searching major crime scenes in a strictly sequential manner and outlines the procedures to be taken in each step. Emphasized in this article are the roles of a variety of professionals that, when acting in a coordinated and cooperative manner, may better serve the public.